120 Capsules Allergen-Free
900 mg Each of Pure TMG
Serving Size 2 Capsules
Combination Product
TMG 甲基化要点
TMG 甲基化要点
120 Capsules Allergen-Free
900 mg Each of Pure TMG
Serving Size 2 Capsules
Combination Product
Details
Trimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.†
Methylation is a chemical process that happens in every cell of your body and it’s essential for:
- Making energy
- Repairing cells
- Regulating gene expression
Each capsule contains
One Serving of 2 Capsules Contains ▸900 mg TMG ▸12 mg Zinc ▸ 1000 mcg Folate ▸ 30 mcg B12 ▸ 5.1 mcg B6
Nutrients to Support Methylation
TMG is a methyl donor, meaning that it provides more methyl groups to support methylation.† In addition to TMG, methylation pathways require other essential nutrients to function effectively, including Folate, Vitamin B6, Vitamin B12, and Zinc.†
“The changes in DNA methylation across a lifespan is a hallmark of aging.” (1)
Aging and Methylation Issues
Research indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.†
“Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.” ⑵
Methylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.†
NAD* Precursors and Methylation Pathways
When taking standard (non-Liposomal) NMN or NR, the compounds are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.†
“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (4)
It has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (5) This is why NAD⁺ precursors are often supplemented with TMG and other compounds that support methylation pathways.†
Acid Resistant Enteric Capsules
Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant™ Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.
三甲基甘氨酸 (TMG),也称为甜菜碱,是一种对甲基化很重要的天然化合物,甲基化是健康衰老和长寿所必需的重要细胞过程。†
甲基化是发生在人体每个细胞中的化学过程,它对于以下方面至关重要:
- 制造能源
- 修复细胞
- 调节基因表达
支持甲基化的营养素
TMG 是一种甲基供体,这意味着它提供更多的甲基来支持甲基化。† 除了 TMG,甲基化途径还需要其他必需营养素才能有效发挥作用,包括叶酸、维生素 B6、维生素 B12 和锌。†
“DNA甲基化在一生中的变化是衰老的标志。”( 1 )
衰老和甲基化问题
研究表明,甲基化途径会随着年龄的增长而发生变化,导致与年龄相关的健康问题和免疫功能受损。†
“最近的研究成果为衰老和与年龄相关的疾病中全基因组DNA甲基化改变提供了令人信服的证据。” (2)
甲基化问题也会导致高同型半胱氨酸水平,这与多种疾病和严重的医疗状况有关。†
NAD+ 前体和甲基化途径
服用标准(非脂质体)NMN 或 NR 时,这些化合物在到达肝脏以外的组织之前几乎完全降解为 NAM(烟酰胺)。适量的 NAM 对许多健康状况有益。但是,过量的 NAM 可能会损害您的健康。†
“高剂量的 NAM 会导致基因组不稳定,减少细胞甲基库,并通过甲基化的 NAM 导致胰岛素抵抗。”( 4 )
研究表明,高剂量的烟酰胺 (NAM) 会降低血浆甜菜碱水平,并减少循环中可用的甲基基团。† ( 5 ) 这就是为什么 NAD+ 前体通常会补充 TMG 和其他支持甲基化途径的化合物。†
耐酸肠溶胶囊
完好无损地到达小肠对于最大限度地吸收至关重要。我们的耐酸™肠溶胶囊经过精心设计,能够穿过胃部严酷的酸性环境而不会降解。只有当它们到达小肠的碱性环境时,它们才会释放有效载荷。
认证
科学支持
All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.
We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.
Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.
常见问题
TMG 常见问题解答
How does TMG help with methylation support?
In certain cases, taking NAD⁺ boosting supplements can deplete levels of methyl groups in the body. TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate As NAD⁺ gets used, it is broken down into Nicotinamide (NAM).
Learn more on the Bioavailability Page here.
Is it necessary to take TMG with NMN?
There is no research that says normal dosages (less that 1,000mg) of NMN or NR deplete methyls and require TMG.
However, it is possible and TMG may help some people.
Dr. Sinclair started recommending taking TMG just in case, as it is very safe and may help.
We now sell TMG here.
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