Scientific Evidence Library

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Scientific Evidence Library

article-page-carousel-item--NAD+ and Brain Health: Neuroprotective Mechanisms Explained

NAD+ and Brain Health: Neuroprotective Mec...

13 min

Nicotinamide adenine dinucleotide (NAD+) has become one of the most buzzworthy supplements on the market, thanks to its powerful neuroprotective properties and potential to boost brain health. In fact, NAD+...

13 min

NAD+ and Brain Health: Neuroprotective Mechanis...

Nicotinamide adenine dinucleotide (NAD+) has become one of the most buzzworthy supplements on the market, thanks...

article-page-carousel-item--Resveratrol and NMN Restore Brain Metabolism and Reduce Inflammation in Smoke-Exposed Aged Mice

Resveratrol and NMN Restore Brain Metaboli...

4 min

Key Points Wood smoke impaired brain chemistry and behavior Resveratrol + NMN provided the strongest protection Combination therapies showed mixed results NAD+ proved to be a key target for protecting...

4 min

Resveratrol and NMN Restore Brain Metabolism an...

Key Points Wood smoke impaired brain chemistry and behavior Resveratrol + NMN provided the strongest protection...

article-page-carousel-item--NMN Improves Movement and Brain Health in a Parkinson’s Disease Mouse Model

NMN Improves Movement and Brain Health in ...

5 min

Key Points: NMN restored NAD+ levels and improved motor performance in Parkinson’s disease (PD) model mice. It reduced inflammation, prevented synaptic loss, and lowered harmful brain immune activity (gliosis). The...

5 min

NMN Improves Movement and Brain Health in a Par...

Key Points: NMN restored NAD+ levels and improved motor performance in Parkinson’s disease (PD) model mice....

article-page-carousel-item--Trigonelline Improves Healing and Reduces Damage After Spinal Cord Injury in Rats

Trigonelline Improves Healing and Reduces ...

6 min

β€œTrigonelline shows neuroprotective properties in SCI rats by reducing allodynia, hyperalgesia, and inflammation, stabilizing mitochondrial enzyme complexes, and modulating apoptotic and neurotrophic factors.”

6 min

Trigonelline Improves Healing and Reduces Damag...

β€œTrigonelline shows neuroprotective properties in SCI rats by reducing allodynia, hyperalgesia, and inflammation, stabilizing mitochondrial enzyme...

article-page-carousel-item--NMN Enhanced Mitochondrial Stress Response and Improved Cognition in an Alzheimer’s Mouse Model

NMN Enhanced Mitochondrial Stress Response...

6 min

β€œWe combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway by which NAD+-boosting agent nicotinamide mononucleotide (NMN) regulates MSR in AD models.”

6 min

NMN Enhanced Mitochondrial Stress Response and ...

β€œWe combined cell biology, molecular biology, and pharmacological approaches to unravel a novel molecular pathway by...

article-page-carousel-item--NMN Offers More Protection Than NR in Friedreich’s Ataxia Mice

NMN Offers More Protection Than NR in Frie...

4 min

Key Points: NMN and NR provided several benefits in mice with FRDA and highlighted key differences between the two treatments: NMN more effectively restored NAD+ levels in the heart than...

4 min

NMN Offers More Protection Than NR in Friedreic...

Key Points: NMN and NR provided several benefits in mice with FRDA and highlighted key differences...

article-page-carousel-item--NMN Enhances Cellular Protection and Cognitive Function in Alzheimer’s Disease Mice

NMN Enhances Cellular Protection and Cogni...

5 min

Key Points Treatment with NMN showed several benefits for mice with AD: Enhanced cognition and memory Reduced neuronal injury Promoted clearance of abnormal tau protein Activated autophagy Enhanced antioxidant defense...

5 min

NMN Enhances Cellular Protection and Cognitive ...

Key Points Treatment with NMN showed several benefits for mice with AD: Enhanced cognition and memory...

article-page-carousel-item--Berberine Improves Motor Function in a Rat Model of Parkinson's Disease

Berberine Improves Motor Function in a Rat...

3 min

Key Points: Berberine supplementation displayed therapeutic benefits for managing Parkinson’s disease symptoms: Improved motor function and coordination Reduced oxidative stress and enhanced antioxidant defenses Restored mitochondrial function Decreased neuroinflammation and...

3 min

Berberine Improves Motor Function in a Rat Mode...

Key Points: Berberine supplementation displayed therapeutic benefits for managing Parkinson’s disease symptoms: Improved motor function and...

article-page-carousel-item--NMN Nanoparticles Outperform Free NMN for Anti-Aging in Mice

NMN Nanoparticles Outperform Free NMN for ...

4 min

This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of aging mice.

4 min

NMN Nanoparticles Outperform Free NMN for Anti-...

This study investigated the potential of NMN-loaded nanoparticles to prevent age-related decline in a model of...

article-page-carousel-item--EGCG Injection from Green Tea Protects Brain Cells and Motor Control in Mice

EGCG Injection from Green Tea Protects Bra...

3 min

EGCG showed several benefits in mice with damaged neurons: Reduced anxiety-like behaviors and motor impairment Reduced degeneration of key brain cells controlling movement Lowered accumulation of harmful proteins linked to...

3 min

EGCG Injection from Green Tea Protects Brain Ce...

EGCG showed several benefits in mice with damaged neurons: Reduced anxiety-like behaviors and motor impairment Reduced...

article-page-carousel-item--Liposomal delivery of NR shows increased bioavailability

Liposomal delivery of NR shows increased b...

2 min

"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."

2 min

Liposomal delivery of NR shows increased bioava...

"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially...

article-page-carousel-item--Neuroprotective Effects of NAD+ Nasal Spray

Neuroprotective Effects of NAD+ Nasal Spray

3 min

"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast...

3 min

Neuroprotective Effects of NAD+ Nasal Spray

"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to...