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Combination Product

全面 NAD+ 恢复方案

全面 NAD+ 恢复方案

全面防御衰老损伤
常规价格 $319.00 AUD
促销价 $319.00 AUD 常规价格
结账时计算的运费

Total NAD+ 修复协议旨在全面防御衰老造成的损害。

该项研究支持的方案包括 NAD+ 前体、抗衰老物质、CD38 抑制剂和促进恢复力和休息的成分的脂质体混合物,是解决 NAD+ 衰退和年轻功能丧失的最先进答案。†

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Combination Product

Total NAD+ Restoration Protocol Details

The Total NAD+ Restoration Protocol is designed to enhance NAD+ production, protect against NAD+ loss through CD38 enzymes, senescent cell accumulation, and inflammation, as well as support energy production, stress resilience, DNA integrity, and deep sleep.

The Total NAD+ Restoration Protocol is a scientifically designed kit that supports youthful NAD+ levels, a coenzyme involved in cellular metabolism, DNA repair, and signaling pathways.

By targeting multiple mechanisms that contribute to NAD+ decline, such as CD38 enzyme activity, senescent cell accumulation, and inflammation, this protocol supports energy production, stress resilience, genomic stability, and circadian rhythm regulation.

The ingredients used in these formulas are poorly absorbed on their own, with only 5-10% bioavailability. By using liposomal forms of these ingredients, the bioavailability is increased to over 90%.

Lipo NAD+ Complete is a comprehensive liposomal formulation that incorporates essential NAD+ precursors to support cellular NAD+ biosynthesis.

  • NAD+: This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
  • NMN: This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
  • NR: This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.
  • Trigonelline: Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Senolytique is designed to selectively eliminate senescent cells, which accumulate with age, secrete pro-inflammatory factors known as the senescence-associated secretory phenotype (SASP), and contribute to chronic inflammation and tissue dysfunction. The accumulation of senescent cells has been tied to various age-related pathologies, including cardiovascular disease, neurodegeneration, and metabolic disorders.

  • Quercetin and Fisetin: These flavonoids exhibit potent senolytic properties by inducing apoptosis in senescent cells through the inhibition of pro-survival pathways. Quercetin has been shown to inhibit the PI3K/AKT pathway, which is overactivated in senescent cells and contributes to their resistance to apoptosis. Fisetin, on the other hand, downregulates the expression of anti-apoptotic proteins, such as BCL-2 and BCL-XL, thereby sensitizing senescent cells to apoptotic stimuli. Moreover, both quercetin and fisetin have been reported to attenuate the SASP by modulating the NF-κB and p38 MAPK signaling pathways, which are key regulators of pro-inflammatory gene expression.
  • Spermidine: This polyamine induces autophagy, a cellular process that facilitates the degradation of damaged proteins and organelles, thereby promoting cellular renewal and longevity. Spermidine activates the autophagy-initiating kinase, ULK1, and inhibits the mTORC1 complex, a negative regulator of autophagy. Furthermore, spermidine has been shown to enhance the expression of key autophagy-related genes, such as ATG5 and ATG7, through epigenetic modifications. By promoting the autophagic clearance of senescent cells and their associated SASP factors, spermidine contributes to the maintenance of tissue homeostasis and the attenuation of age-related functional decline.

Energizer AM focuses on optimizing mitochondrial function and cellular energy production to combat fatigue and support stable all-day energy. Mitochondrial dysfunction is a hallmark of aging and is associated with reduced ATP synthesis, increased oxidative stress, and impaired metabolic flexibility.

  • Hesperidin: This bioflavonoid supports mitochondrial respiration and ATP synthesis by modulating the activity of key enzymes involved in the electron transport chain and citric acid cycle. Hesperidin has been shown to increase the expression and activity of citrate synthase, a rate-limiting enzyme in the citric acid cycle, thereby promoting efficient substrate utilization and energy production. Additionally, hesperidin scavenges reactive oxygen species (ROS) and upregulates antioxidant enzymes, such as superoxide dismutase and catalase, protecting mitochondria from oxidative damage.
  • Trans-Resveratrol and Epigallocatechin Gallate (EGCG): These polyphenols activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate diverse cellular processes, including mitochondrial biogenesis, antioxidant defenses, and metabolic pathways. Resveratrol and EGCG have been shown to activate SIRT1 by increasing NAD+ levels and promoting the deacetylation of PGC-1α, a master regulator of mitochondrial biogenesis. Furthermore, these polyphenols modulate the activity of AMP-activated protein kinase (AMPK), a key energy sensor that stimulates mitochondrial function and fatty acid oxidation.

Restore PM supports deep, restorative sleep cycles and built-in restorative processes by modulating neurotransmitter signaling and protecting against oxidative stress. Sleep disturbances and chronic stress are associated with impaired cognitive function, metabolic dysregulation, and accelerated aging.

  • Gamma-Aminobutyric Acid (GABA) and 5-Hydroxytryptophan (5-HTP): These neurotransmitter precursors promote relaxation and enhance sleep quality by modulating the activity of GABA and serotonin receptors, respectively. GABA is the primary inhibitory neurotransmitter in the central nervous system, and its signaling reduces neuronal excitability and promotes sleep onset. 5-HTP, on the other hand, is a precursor to serotonin, a neurotransmitter involved in regulating mood, appetite, and sleep-wake cycles. Supplementation with GABA and 5-HTP has been shown to improve sleep latency, duration, and efficiency, as well as reduce feelings of anxiety and stress-related symptoms.
  • Apigenin: This flavonoid exhibits anxiolytic and sedative properties by interacting with GABA receptors and promoting neuroprotection through its anti-inflammatory effects. Apigenin has been shown to bind to sites on GABA-A receptors, enhancing the inhibitory effects of GABA and promoting relaxation. Moreover, apigenin modulates neuroinflammation by inhibiting the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, and reducing the activation of microglial cells, which are key mediators of neuroinflammation.
  • Glutathione and Melatonin: These potent antioxidants protect neural cells from oxidative damage, support detoxification processes, and regulate the circadian rhythm, thereby promoting restorative sleep. Glutathione is the master antioxidant in the body, neutralizing ROS, detoxifying xenobiotics, and maintaining redox homeostasis. Melatonin, a hormone primarily secreted by the pineal gland, regulates the sleep-wake cycle and exhibits strong antioxidant properties. Melatonin has been shown to scavenge free radicals, enhance the activity of antioxidant enzymes, and protect mitochondria from oxidative stress. Furthermore, melatonin modulates the expression of clock genes, maintaining circadian rhythms and promoting healthy sleep patterns.
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NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平,以维持健康的能量、力量和认知。

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平,以维持健康的能量、力量和认知。

完整的 NAD+ 支持

全面 NAD+ 恢复协议旨在增强 NAD+ 的产生,防止 NAD+ 通过 CD38 酶、衰老细胞积累和炎症而流失,以及支持能量产生、压力恢复力、DNA 完整性和深度睡眠。


总体 NAD+ 恢复协议是一种科学设计的套件,可支持年轻的 NAD+ 水平,NAD+ 是一种参与细胞代谢、DNA 修复和信号通路的辅酶。


通过针对导致 NAD+ 下降的多种机制,例如 CD38 酶活性、衰老细胞积累和炎症,该协议支持能量产生、压力恢复力、基因组稳定性和昼夜节律调节。


这些配方中使用的成分本身吸收不良,生物利用度仅为 5-10%。通过使用脂质体形式,这些成分的生物利用度可提高到 90% 以上。


Lipo NAD+ Complete是一种综合脂质体配方,包含必需的 NAD+ 前体来支持细胞 NAD+ 生物合成。

  • NAD+:这种中心辅酶直接参与氧化还原反应,并作为能量产生酶活性的底物,包括sirtuins和聚(ADP-核糖)聚合酶(PARPs),它们调节细胞代谢、DNA修复和表观遗传修饰。
  • NMN:这种 NAD+ 前体通过 Salvage 途径中的 NMNAT 酶直接转化为 NAD+,大量临床试验表明其可有效提高细胞内 NAD+ 水平,从而增强线粒体功能、能量产生和 NAD+ 依赖性酶的活性。
  • NR:这种 NAD+ 前体通过 Preiss-Handler 途径转化为 NAD+,还表现出提高细胞中 NAD+ 水平的能力。它支持细胞修复机制,特别是那些涉及 DNA 损伤反应和氧化应激缓解的机制。通过支持 NAD+ 水平,NR 促进 sirtuins 和 PARP 的激活,从而保护基因组稳定性并调节细胞代谢。
  • 葫芦巴碱:葫芦巴碱促进细胞 NAD+ 生成的方式与 NMN 或 NR 不同。这种甲基化形式的烟酸具有多种优势:在血流中具有出色的稳定性、缓慢释放到目标组织中、不潮红、防止胃消化以及直接增加肌肉组织中的 NAD+。

Senolytique旨在选择性地消除衰老细胞。衰老细胞会随着年龄的增长而积累,分泌促炎因子(称为衰老相关分泌表型 (SASP)),并导致慢性炎症和组织功能障碍。衰老细胞的积累与各种与年龄相关的病症有关,包括心血管疾病、神经退化和代谢紊乱。

  • 槲皮素和非瑟酮:这些黄酮类化合物通过抑制促存活途径诱导衰老细胞凋亡,从而表现出强大的抗衰老特性。槲皮素已被证明可以抑制 PI3K/AKT 通路,该通路在衰老细胞中过度激活,并有助于其抵抗凋亡。另一方面,非瑟酮会下调抗凋亡蛋白(如 BCL-2 和 BCL-XL)的表达,从而使衰老细胞对凋亡刺激敏感。此外,据报道,槲皮素和非瑟酮都通过调节 NF-κB 和 p38 MAPK 信号通路来减弱 SASP,而 NF-κB 和 p38 MAPK 信号通路是促炎基因表达的关键调节因子。
  • 亚精胺:这种多胺可诱导自噬,这是一种促进受损蛋白质和细胞器降解的细胞过程,从而促进细胞更新和长寿。亚精胺可激活自噬启动激酶 ULK1,并抑制 mTORC1 复合物(自噬的负调节剂)。此外,亚精胺已被证明可通过表观遗传修饰增强关键自噬相关基因(如 ATG5 和 ATG7)的表达。通过促进衰老细胞及其相关 SASP 因子的自噬清除,亚精胺有助于维持组织稳态并减轻与年龄相关的功能衰退。


Energizer AM专注于优化线粒体功能和细胞能量产生,以对抗疲劳并支持全天稳定的能量。线粒体功能障碍是衰老的标志,与 ATP 合成减少、氧化应激增加和代谢灵活性受损有关。

  • 橙皮苷:这种生物类黄酮通过调节参与电子传递链和柠檬酸循环的关键酶的活性来支持线粒体呼吸和 ATP 合成。橙皮苷已被证明可以增加柠檬酸合酶(柠檬酸循环中的限速酶)的表达和活性,从而促进有效的底物利用和能量产生。此外,橙皮苷可以清除活性氧 (ROS) 并上调抗氧化酶,如超氧化物歧化酶和过氧化氢酶,保护线粒体免受氧化损伤。
  • 反式白藜芦醇和表没食子儿茶素没食子酸酯 (EGCG):这些多酚可激活 sirtuins,特别是 SIRT1,它们是 NAD+ 依赖性脱乙酰酶,可调节多种细胞过程,包括线粒体生物合成、抗氧化防御和代谢途径。白藜芦醇和 EGCG 已被证明可通过增加 NAD+ 水平和促进线粒体生物合成的主要调节剂 PGC-1α 的脱乙酰化来激活 SIRT1。此外,这些多酚还能调节 AMP 活化蛋白激酶 (AMPK) 的活性,AMPK 是一种刺激线粒体功能和脂肪酸氧化的关键能量传感器。


Restore PM通过调节神经递质信号和防止氧化应激来支持深度恢复性睡眠周期和内置恢复过程。睡眠障碍和慢性压力与认知功能受损、代谢失调和加速衰老有关。

  • γ-氨基丁酸 (GABA) 和 5-羟色氨酸 (5-HTP):这些神经递质前体分别通过调节 GABA 和血清素受体的活性来促进放松和提高睡眠质量。GABA 是中枢神经系统中的主要抑制性神经递质,其信号传导可降低神经元兴奋性并促进睡眠开始。另一方面,5-HTP 是血清素的前体,血清素是一种参与调节情绪、食欲和睡眠-觉醒周期的神经递质。补充 GABA 和 5-HTP 已被证明可以改善睡眠潜伏期、持续时间和效率,以及减少焦虑感和压力相关症状。
  • 芹菜素:这种类黄酮通过与 GABA 受体相互作用,发挥抗焦虑和镇静作用,并通过其抗炎作用促进神经保护。芹菜素已被证明能与 GABA-A 受体上的位点结合,增强 GABA 的抑制作用并促进放松。此外,芹菜素通过抑制促炎细胞因子(如 TNF-α 和 IL-1β)的产生,并减少小胶质细胞(神经炎症的关键介质)的激活来调节神经炎症。
  • 谷胱甘肽和褪黑激素:这些强效抗氧化剂可保护神经细胞免受氧化损伤,支持排毒过程,调节昼夜节律,从而促进恢复性睡眠。谷胱甘肽是体内的主要抗氧化剂,可中和活性氧 (ROS)、解毒外来生物并维持氧化还原稳态。褪黑激素是一种主要由松果体分泌的激素,可调节睡眠-觉醒周期并具有强大的抗氧化特性。褪黑激素已被证明可以清除自由基、增强抗氧化酶的活性并保护线粒体免受氧化应激。此外,褪黑激素还可以调节时钟基因的表达,维持昼夜节律并促进健康的睡眠模式。

哪种 NAD+ 前体最好?

NAD+

这种中心辅酶直接参与氧化还原反应,并作为能量产生酶活性的底物,包括 sirtuins 和聚(ADP-核糖)聚合酶 (PARPs),它们调节细胞代谢、DNA 修复和表观遗传修饰。

纳米二核苷酸

这种 NAD+ 前体通过 Salvage 途径中的 NMNAT 酶直接转化为 NAD+,已被大量临床试验证明可以有效提高细胞内 NAD+ 水平,从而增强线粒体功能、能量产生和 NAD+ 依赖性酶的活性。

天然橡胶

这种 NAD+ 前体通过 Preiss-Handler 途径转化为 NAD+,还表现出提高细胞中 NAD+ 水平的能力。它支持细胞修复机制,特别是那些涉及 DNA 损伤反应和氧化应激缓解的机制。通过支持 NAD+ 水平,NR 促进 sirtuins 和 PARP 的激活,从而保护基因组稳定性并调节细胞代谢。

葫芦巴碱

葫芦巴碱促进细胞 NAD+ 生成的方式与 NMN 或 NR 不同。这种甲基化形式的烟酸具有多种优势:在血流中具有出色的稳定性、缓慢释放到目标组织中、不会引起潮红、防止胃消化以及直接增加肌肉组织中的 NAD+。

提高生物利用度

脂质体递送

脂质体是一种革命性的方法,将活性成分封装在磷脂“气泡”中,以保护活性成分并将其直接输送到组织细胞,然后通过血液到达。 (1)这样可以使成分被吸收和利用,而不会在胃中被破坏。

服用任何补充剂的目的是确保其进入血液。然而,由于传统口服胶囊的吸收率和生物利用度较低,活性成分在通过胃肠道时会失去大部分效力,或者根本无法在小肠中吸收。大多数未经利用就通过肠道或肾脏排出体外。 (2)

脂质体递送可实现活性成分的定向和完全吸收,具有延迟释放效果,与所有其他营养递送方法不同。关键营养素在血液中的循环时间增加,显著提高了生物利用度。活性物质的生物利用度越高,其对身体的影响就越大。

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研究

脂质体提高生物利用度

使用我们的脂质体产品,无论有效载荷是什么,大约 90% 的有效载荷都能完整地到达血液

例如,我们的脂质体绿茶提取物中约 90% 的 EGCG 能够到达血液。

通过常规绿茶提取物,约有9% 的 EGCG 会进入血液。

因此,下面的研究表明它的生物利用度大约高出 10 倍。

常规芹菜素的生物利用度约为 30% ,因此,您可以预期我们的脂质体芹菜素的生物利用度比常规芹菜素高出约 3 倍。

虽然我们没有对所有脂质体产品的生物利用度进行研究,但下面我们展示的研究表明,在我们生产的一些最受欢迎的补充剂中使用脂质体时,生物利用度提高了 3 到 40 倍。

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