トリゴネリンは、NMN や NR などの他の前駆体とは異なる方法で細胞内の NAD+ 生成を促進します。
このメチル化された形態のナイアシンは、ビタミン B の他の形態に比べて次のような利点があります。
- 血流中の優れた安定性
- 標的組織への徐放
- 非フラッシュ
- 胃での消化から保護
- 筋肉内のNAD+を直接増加させます(NMNやNRとは異なります)
トリゴネリンは、NMN や NR などの他の前駆体とは異なる方法で細胞内の NAD+ 生成を促進します。
このメチル化された形態のナイアシンは、ビタミン B の他の形態に比べて次のような利点があります。
250mg Trigonelline
This methylated form of Niacin has advantages over other forms of this B vitamin:
Trigonelline (methylated niacin) is an NAD+ precursor that promotes NAD+ production in muscle cells, a property not observed in other NAD+ boosters like NMN or NR. It accomplishes this through conversion in the Preiss-Handler pathway, unlike other NAD+ precursors which utilize the Salvage pathway. Its innate bioavailable structure allows it to survive digestion, cross the blood-brain barrier, and directly stimulate NAD+ production in muscle, brain, and other tissues.
Trigonelline, as a methylated form of Niacin, actively promotes NAD+ restoration in muscle cells. While NMN and NR can increase NAD+ metabolites in muscle, there has been no evidence to indicate that either of these precursors actively increase NAD+ concentration in muscle, making Trigonelline the only precursor known to have this benefit.
Research shows that Trigonelline remains stable in circulation for more than 72 hours, compared to NR and NMN which are both rapidly degraded to NAM within only a few hours.
Consistent Trigonelline use can elevate NAD+ levels to support critical cellular functions including energy production, DNA repair, and cellular signaling:
Trigonelline’s bioavailability and ability to cross the blood-brain barrier enable it to exert systemic benefits, supporting cognitive, cardiovascular, and metabolic health. It supports in glucose regulation by enhancing insulin receptor signaling and facilitates lipid management by influencing key enzymes in lipid metabolism.
NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.
NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.
Trigonelline (methylated niacin) is an NAD+ precursor that promotes NAD+ production in muscle cells, a property not observed in other NAD+ boosters like NMN or NR. It accomplishes this through conversion in the Preiss-Handler pathway, unlike other NAD+ precursors which utilize the Salvage pathway. Its innate bioavailable structure allows it to survive digestion, cross the blood-brain barrier, and directly stimulate NAD+ production in muscle, brain, and other tissues.
.
Trigonelline, as a methylated form of Niacin, actively promotes NAD+ restoration in muscle cells. While NMN and NR can increase NAD+ metabolites in muscle, there has been no evidence to indicate that either of these precursors actively increase NAD+ concentration in muscle, making Trigonelline the only precursor known to have this benefit.
.
Research shows that Trigonelline remains stable in circulation for more than 72 hours, compared to NR and NMN which are both rapidly degraded to NAM within only a few hours.
.
Consistent Trigonelline use can elevate NAD+ levels to support critical cellular functions including energy production, DNA repair, and cellular signaling:
.
Trigonelline’s bioavailability and ability to cross the blood-brain barrier enable it to exert systemic benefits, supporting cognitive, cardiovascular, and metabolic health. It supports in glucose regulation by enhancing insulin receptor signaling and facilitates lipid management by influencing key enzymes in lipid metabolism.
This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.
Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.
How Trigonelline Works
How Trigonelline Works
How Trigonelline Works
Certifications
Supported by Science
All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.
We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.
Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.
カプセル
リポソームベルベリン、レッドイーストライス、CoQ10
120カプセル
舌下ジェル
骨のミネラル化と成長に必須のビタミン
120 mL / 4 液量オンス
カプセル
NAD⁺、NMN、NR、トリゴネリン(リポソーム)
120カプセル
鼻スプレー
便利な認知力の向上
30mL/1液量オンス
カプセル
吸収性を高めるために遅延放出
60カプセル
舌下粉末
素早く溶解するNAD+増強パウダー
100グラム
舌下ジェル
細胞の活力と健康
150 mL / 5 液量オンス
舌下粉末
舌下シトラスバーストNAD+ブースト
77グラム
カプセル
NAD+生成のための天然の構成要素
90カプセル
経口スプレー
素早く吸収され、素早くエネルギーを供給
30mL / 1液量オンス
血清
肌の自然な輝きを取り戻す
血清
強力な肌の若返り
50mL / 1.7液量オンス
クリーム
強力な肌の若返り
60 mL / 2 液量オンス
舌下スプレー
急速吸収睡眠サポート
30mL / 1液量オンス
舌下ジェル
炎症をサポートする生体利用可能な処方
150 mL / 5 液量オンス
カプセル
細胞の健康と若返りをサポート
60カプセル
スキン&ボディエッセンシャル
グラスフェッドコラーゲン + クレアチン + BCAA + 電解質ドリンクミックス
ドリンクミックス
グラスフェッドコラーゲン + クレアチン + BCAA + 電解質ドリンクミックス
31.96オンス / 906グラム
スキン&ボディエッセンシャル
グラスフェッドコラーゲン + クレアチン + BCAA + 電解質ドリンクミックス
カプセル
遅延放出NAD+ブースター
60カプセル
カプセル
遅延放出NAD+ブースター
60カプセル
† These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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