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120 Capsules Allergen-Free

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900 mg Each of Pure TMG

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Serving Size 2 Capsules

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Combination Product

TMGメチル化の基本

TMGメチル化の基本

通常価格 ¥4,300 JPY
セール価格 ¥4,300 JPY 通常価格
配送料はチェックアウト時に計算されます。

TMG メチル化エッセンシャルは、最適なメチル化をサポートするために重要な栄養素を組み合わせています。† この配合は、細胞機能のピーク、DNA 保護、健康的な老化を可能にするように作られています。†

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120 Capsules Allergen-Free

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900 mg Each of Pure TMG

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Serving Size 2 Capsules

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Combination Product

詳細を表示する

Trimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.†

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Nutrients to Support Methylation

TMG is a methyl donor, meaning that it provides more methyl groups to support methylation.† In addition to TMG, methylation pathways require other essential nutrients to function effectively, including Folate, Vitamin B6, Vitamin B12, and Zinc.†

“The changes in DNA methylation across a lifespan is a hallmark of aging.” (1)

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Aging and Methylation Issues

Research indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.†

“Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.” 

Methylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.†

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NAD+ Precursors and Methylation Pathways

When taking standard (non-Liposomal) NMN or NR, the compounds are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.†

“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (4)

It has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (5) This is why NAD+ precursors are often supplemented with TMG and other compounds that support methylation pathways.†

Acid Resistant Enteric Capsules

​​Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant™ Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification

Strength and Purity Certification

Open Certification
Gold Standard Testing

Gold Standard Testing

Open Certification
TMG-Test-Report

TMG-Test-Report

Open Certification

Frequently Asked Questions

LIPO APIGENIN

How does TMG help with methylation support?

In certain cases, taking NAD⁺ boosting supplements can deplete levels of methyl groups in the body. TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate As NAD⁺ gets used, it is broken down into Nicotinamide (NAM).

Learn more on theBioavailability Page here.

Is it necessary to take TMG with NMN?

There is no research that says normal dosages (less that 1,000mg) of NMN or NR deplete methyls and require TMG.

However, it is possible and TMG may help some people.

Dr. Sinclair started recommending taking TMG just in case, as it is very safe and may help.

We now sell TMG here.

Customer Reviews

Based on 12 reviews
75%
(9)
8%
(1)
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8%
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Anonymous
It’s been less than a month since I purchased and I haven’t seen the differences yet

It’s been less than a month since I purchased and I haven’t seen the differences yet. I’m not sure what to expect either. I’m still feeling exhausted and haven’t had good sleep lately.

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M
TMG Methylation Essentials

I don't know why it took me so long to try pairing this with my NAD Complete/NMN but holy wow! It's only been a week since I added it to my daily regimen and I feel amazing!!

K
Kevin Keown

I love your products. I am also referring g others to your company. Great product and 5 Stars all the way!!!!

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Lauritz Hanson
Ammonia levels too highsx

Now when I go I dont notice what seems to be a faint ammonia odor and my tummy feels a lot better with a occasional tmg capsule. At my age converting ammonia to urine so it can pass has declined. It's good to know of a practical solution to a chronic issue.

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Roosevelt Poellnitz

Excellent product