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120 Capsules Allergen-Free

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900 mg Each of Pure TMG

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Serving Size 2 Capsules

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Combination Product

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Product ID: 7844075176115
Product Handle: tmg-methylation-essentials-120-ct

All custom metafields:
- active_ingredient: TMG (Trimethylglycine), Vitamin B6, Folate, Vitamin B12, Zinc
- alternative_title: TMGメチル化の基本
- byline: Healthy Methylation
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- coa_test_date: 2025-04-16
- delivery_mechanism: enteric capsule, capsule
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- dosage_per_serving: TMG: 900 mg; Vitamin B12: 30 mcg; Zinc: 12 mg; Vitamin B6: 5.1 mg; Folate: 1000 mcg DFE
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- servings_per_container: 60
- specification: 120カプセル
- stacking_rationale: NAD+ Complete (methylation supports NAD+ metabolism), Senolytique (PROTECT pathway coverage), Energizer AM (OPTIMIZE pathway coverage), Restore PM (REGENERATE pathway coverage)
- testing_lab: TL Laboratories
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TMGメチル化の基本

TMGメチル化の基本

Healthy Methylation

通常価格 ¥4,600 JPY
セール価格 ¥4,600 JPY 通常価格
4.6
Rated 4.6 out of 5 stars
23 Reviews
配送料はチェックアウト時に計算されます。

TMG メチル化エッセンシャルは、最適なメチル化をサポートするために重要な栄養素を組み合わせています。† この配合は、細胞機能のピーク、DNA 保護、健康的な老化を可能にするように作られています。†

image

120 Capsules Allergen-Free

image

900 mg Each of Pure TMG

image

Serving Size 2 Capsules

image

Combination Product

詳細を表示する

Trimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.†

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Nutrients to Support Methylation

TMG is a methyl donor, meaning that it provides more methyl groups to support methylation.† In addition to TMG, methylation pathways require other essential nutrients to function effectively, including Folate, Vitamin B6, Vitamin B12, and Zinc.†

“The changes in DNA methylation across a lifespan is a hallmark of aging.” (1)

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Aging and Methylation Issues

Research indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.†

“Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.” 

Methylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.†

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NAD+ Precursors and Methylation Pathways

When taking standard (non-Liposomal) NMN or NR, the compounds are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.†

“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (4)

It has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (5) This is why NAD+ precursors are often supplemented with TMG and other compounds that support methylation pathways.†

Acid Resistant Enteric Capsules

​​Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant™ Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification

Strength and Purity Certification

Open Certification
Gold Standard Testing

Gold Standard Testing

Open Certification
TMG-Test-Report

TMG-Test-Report

Open Certification

Frequently Asked Questions

LIPO APIGENIN

How does TMG help with methylation support?

In certain cases, taking NAD⁺ boosting supplements can deplete levels of methyl groups in the body. TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate As NAD⁺ gets used, it is broken down into Nicotinamide (NAM).

Learn more on theBioavailability Page here.

Is it necessary to take TMG with NMN?

There is no research that says normal dosages (less that 1,000mg) of NMN or NR deplete methyls and require TMG.

However, it is possible and TMG may help some people.

Dr. Sinclair started recommending taking TMG just in case, as it is very safe and may help.

We now sell TMG here.

4.6
Rated 4.6 out of 5 stars
Based on 23 reviews
Total 5 star reviews: 18 Total 4 star reviews: 2 Total 3 star reviews: 2 Total 2 star reviews: 0 Total 1 star reviews: 1
87%would recommend this product
23 reviews
  • AM
    Alexander M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    5 Stars

    Love the liposomal form

  • C
    Cruz
    Flag of United States
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Great product!

    Been taking this for the last year with all my other supplements and I’ve noticed such a difference in bioavailability. It definitely feels like my absorption rate is significantly higher compared to when I didn’t have it. My body’s response to repair is quicker.

  • AR
    Ari R.
    Flag of United States
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Can’t live without it now

    Can’t live without it now.

  • DH
    Dalton H.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    2 months ago
    4 Stars

    Awesome product, a little pricey tho

  • N
    Neel
    Flag of Canada
    I recommend this product
    Rated 5 out of 5 stars
    6 months ago
    Good

    Good product