Serving Size 2 Capsules

ニコチンアミドリボシド（NR）1000 mg — 腸溶性コーティング

Name: ニコチンアミドリボシド（NR）1000 mg — 腸溶性コーティング 60 錠
Brand: Renue Store
SKU: 850055685109
Price: 8600.0 JPY
Availability: InStock

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¥8,600 JPY

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NR は、体内で NAD+ を生成するために使われる天然分子です。NR 1000 は、NAD+ レベルを高め、細胞機能を最適化し、全体的な健康と活力を促進するように設計されています。

商品バリエーション

Serving Size 2 Capsules

NR 1000 Details

NAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. By providing Nicotinamide Riboside (NR), a direct precursor to NAD+, NR 1000™ helps boost the production of NAD+.†

“Together, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration.” (1)

NR is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:

Energy production†DNA repair†Regulation of genes†Cellular health and vitality†Immune function†Regulation of the sleep-wake cycle†

Preventing NR Degradation is Essential

Research has shown that NAD+ precursors are largely degraded in the stomach and small intestine to other metabolites that are not as effective.

In a study, the fate of labeled NR was monitored in mice with and without gut bacteria following oral administration. The findings revealed a substantial breakdown of NR by gut bacteria into various metabolites, illustrated in the figure below.

The blue bars represent orally administered NR that has been labeled for detection. In regular mice (Reg NR), a portion of the labeled NR is converted into NAM, NA, and NAR in the colon’s lumen. However, in mice without gut microbiota (GF NR), the conversion of NR to NAM, NA, or NAR is reduced or completely halted, suggesting that gut microbiota plays a significant role in breaking down NR.

Safeguarding NR 1000 From Digestion in the Stomach

Several delivery systems have been developed to protect NAD+ precursors from being broken down and enhance their bioavailability (how much of a substance is absorbed into the bloodstream and can be used by the body).

In other products, we use advanced Liposomal technology, to protect NAD+ precursors from degradation in the GI tract and liver, but this delivery system adds significant cost.

Enteric Capsules Naturally Protect NR 1000™

NR 1000 provides 1000 mg of NR in enteric (acid resistant) capsules that protect the ingredients from harsh stomach acid and early breakdown by gut bacteria. The delayed release of NR ensures optimal absorption and efficiency.

The enteric capsules are naturally resistant to acid, meaning there is no need for harsh chemicals for maximum protection and enhanced stability:

Delayed release
Resistant to gastric acids and ultimately disintegrated in the small intestine
Low moisture content
Stability over a wide range of temperatures and humidity

詳細を表示する

NR is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:

Energy production†
DNA repair†
Regulation of genes†
Cellular health and vitality†
Immune function†
Regulation of the sleep-wake cycle†

Preventing NR Degradation is Essential

Research has shown that NAD+ precursors are largely degraded in the stomach and small intestine to other metabolites that are not as effective.

In regular mice (Reg NR), a portion of the labeled NR is converted into NAM, NA, and NAR in the colon’s lumen. However, in mice without gut microbiota (GF NR), the conversion of NR to NAM, NA, or NAR is reduced or completely halted, suggesting that gut microbiota plays a significant role in breaking down NR.

Safeguarding NR 1000 From Digestion in the Stomach

In other products, we use advanced Liposomal technology, to protect NAD+ precursors from degradation in the GI tract and liver, but this delivery system adds significant cost.

Enteric Capsules Naturally Protect NR 1000™

The enteric capsules are naturally resistant to acid, meaning there is no need for harsh chemicals for maximum protection and enhanced stability:

Delayed release
Resistant to gastric acids and ultimately disintegrated in the small intestine
Low moisture content
Stability over a wide range of temperatures and humidity

NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

Enteric Capsules Protect NR

NAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. Enteric NR capsules help boost NAD+ production by providing NR, a precursor to NAD+, in capsules that are protected from the acidic conditions of the stomach.†

NAD+ levels naturally decline with age, which research suggests is linked to the onset and progression of age-related diseases.† This makes increasing NAD+ levels a promising therapeutic target.†

NMN serves as a precursor to NAD+, acting as a potent booster to elevate your NAD+ levels.†

Enteric NR capsules are designed for enhanced absorption by protecting NR against the acidic conditions of digestion to be taken up by the gut.†

Which NAD+ Precursor Is Best?

NAD+

This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN

This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR

This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline

Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Frequently Asked Questions

How Do Enteric (Acid-Resistant) Capsules Work?

The enteric coated (acid-resistant) capsules are specifically designed to protect ingredients from the harsh acidic stomach, while safeguarding them from being degraded and digested by bacteria and enzymes.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract - with NAD+ precursors being particularly vulnerable to this.

The enteric (acid-resistant) capsules safeguard the ingredients to support better absorption, and a slower release into the bloodstream.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.