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Sublingual

Combination Product

Restore PM Liposomal Sleep Gel

Name: Restore PM Liposomal Sleep Gel
Brand: Renue Store
SKU: 850055685222
Price: 3600.0 JPY
Availability: InStock

Rapid absorption sleep support

¥3,600 JPY

¥3,600 JPY ~~¥4,400~~

Shipping calculated at checkout.

Restore PM™ Liposomal Sleep Gel is designed for rapid absorption through the mucosal lining of the mouth beneath the tongue.

1 mL (6 pumps) provides a concentrated blend of ingredients shown to enhance the quality, duration and impact of your sleep.

Each 1 mL Serving Contains ▸8 mg Liposomal GABA ▸2.5 mg Liposomal Melatonin ▸1 mg Liposomal Glutathione

Product variants

Sublingual

Combination Product

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Rest is Critical to Rejuvenation

Sleep is when the body’s most powerful healing mechanisms activate, driving tissue regeneration, muscle repair, memory consolidation, and immune regulation.

Rest is Critical to Rejuvenation

Sleep is when the body’s most powerful healing mechanisms activate, driving tissue regeneration, muscle repair, memory consolidation, and immune regulation.

Restore PM Protects Your Sleep

Restore PM is formulated with ingredients that work with your body's natural sleep-wake rhythms, without relying on sedatives or habit forming substances.

Each ingredient is available separately in addition to the complete blend, ensuring you have the sleep support you need as a nightly ritual or on those nights when sleep seems most elusive.

GABA
This inhibitory neurotransmitter promotes relaxation and reduces neuronal excitability. Liposomal delivery of GABA enhances its absorption, allowing it to efficiently cross the blood-brain barrier, where it helps to induce calm and support restful sleep. GABAergic activity sets the stage for deep, restorative sleep by allowing the neurons that are overexcited with thoughts and physical stress to instead come to a more restful state, promoting tranquility and restfulness.

5-HTP
5-Hydroxytryptophan (5-HTP) is a direct precursor to serotonin, the neurotransmitter thought to be the most critical for mood regulation and sleep initiation. Liposomal encapsulation of 5-HTP ensures optimal bioavailability, promoting serotonin synthesis in the brain. This facilitates the onset of sleep and stabilizes mood, gently guiding the transition to a restful night.

Apigenin
Apigenin is a bioactive flavonoid that has been shown to modulate GABA receptors and exert anti-inflammatory effects. Found in chamomile, this compound may be responsible for this tea's notorious relaxing effect. Through liposomal delivery, apigenin’s bioavailability is significantly enhanced, enabling it to effectively reduce anxiety and support the onset of sleep. Its dual action on the nervous and immune systems promotes overall relaxation and sleep quality.

Glutathione
As the body's master antioxidant, glutathione supports healthy detoxification, cellular repair, and immune function. Traditional glutathione is poorly absorbed. Liposomal glutathione enhances its ability to neutralize oxidative stress and support brain health during sleep.

Melatonin
Melatonin is the hormone responsible for regulating the sleep-wake cycle, and natural secretion not only diminishes with age, but can be impacted by exposure to unnatural light cycles. Liposomal delivery increases its absorption, supporting rapid onset of sleep by signaling to the brain that it’s time to rest. This helps align your body’s circadian rhythm, promoting a deep and uninterrupted sleep cycle so you wake refreshed and clear-headed in the morning.

Enhanced Bioavailability

Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body.

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Research

Liposomes Increase Bioavailability

With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.

For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.

With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.

Hence the study below shows it is about 10x more bioavailable.

Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.

Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.

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