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Serving size 1 capsule

90 Capsules Allergen-Free

Melatonin (Liposomal)

Name: Melatonin (Liposomal) 90 Ct.
Brand: Renue Store
SKU: 850055685048
Price: 3800.0 JPY
Availability: InStock

Natural hormone for sleep support

¥3,800 JPY

¥3,800 JPY ~~¥4,700~~

Shipping calculated at checkout.

LIPO Melatonin features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect it from digestive enzymes and carry it into the bloodstream for targeted systemic delivery.

LIPO Melatonin is also available in our combination product, Restore PM.

Product variants

Serving size 1 capsule

90 Capsules Allergen-Free

LIPO Melatonin Details

LIPO Melatonin™ promotes high-quality sleep and balances your “body clock.” Benefits may include improvement of sleep onset, sleep pattern and a decrease in cortisol levels.

Offering an advanced liposomal source of the natural hormone—N-acetyl-5-methoxytryptamine—LIPO Melatonin™ is expertly designed to overcome low absorption issues.

Balance Cortisol Levels

Melatonin is mainly known for its ability to regulate the sleep-wake cycle (circadian rhythm or chronobiology) via its release from the pineal gland. Studies demonstrate that melatonin decreases sleep onset latency, increases total sleep time and improves overall sleep quality. 1

In addition to improving sleep, melatonin is also involved in managing immune function, blood pressure and cortisol levels. 2

Only 15% Absorption in Standard Melatonin Supplements

Oral melatonin has an absolute bioavailability of about 15 percent. So, if you take a 4 mg melatonin pill, your body is only absorbing around 0.6 mg. 3

Our encapsulation process in liposomes protects melatonin from premature degradation while enhancing its intestinal absorption.

The absorption of non-liposomal oral melatonin is minimal due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract. 4

Liposomes extend the time a supplement is available in the bloodstream, but the peak availability is between 2 and 4 hours, which is while you are sleeping.

However, some is absorbed well before the 2 hours and actually may work faster than standard Melatonin.

This study found Liposomal Melatonin decreased the time to sleep (Sleep latency – SL). from 18 minutes to 10 minutes.

“A significant difference in SL was observed (10.8 ± 5 vs. 18.1 ± 13.4 min, p-value = 0.002)… Our study confirmed the efficacy and safety of melatonin administration in sleep induction. Nonetheless, liposomal melatonin presents a greater bioavailability, ensuring a faster effect and allowing lower dosages.”

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LIPO Melatonin™ promotes high-quality sleep and balances your “body clock.” Benefits may include improvement of sleep onset, sleep pattern and a decrease in cortisol levels.

Offering an advanced liposomal source of the natural hormone—N-acetyl-5-methoxytryptamine—LIPO Melatonin™ is expertly designed to overcome low absorption issues.

Balance Cortisol Levels

In addition to improving sleep, melatonin is also involved in managing immune function, blood pressure and cortisol levels. 2

Only 15% Absorption in Standard Melatonin Supplements

Oral melatonin has an absolute bioavailability of about 15 percent. So, if you take a 4 mg melatonin pill, your body is only absorbing around 0.6 mg. 3

Our encapsulation process in liposomes protects melatonin from premature degradation while enhancing its intestinal absorption.

The absorption of non-liposomal oral melatonin is minimal due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract. 4

Liposomes extend the time a supplement is available in the bloodstream, but the peak availability is between 2 and 4 hours, which is while you are sleeping.

However, some is absorbed well before the 2 hours and actually may work faster than standard Melatonin.

This study found Liposomal Melatonin decreased the time to sleep (Sleep latency – SL). from 18 minutes to 10 minutes.

Learn More About Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴

This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body.

Learn more

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification Gold Standard Testing Melatonin Report

Frequently Asked Questions

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.