Research
NAD+ and the Hallmarks of Aging Series - Part 6...
These findings suggest that a conserved pathway may operate in mammals during calorie restriction involving the activation of SIRT1 and increased NAD+ that triggers an increase in mitochondrial activity, which...
NAD+ and the Hallmarks of Aging Series - Part 6...
These findings suggest that a conserved pathway may operate in mammals during calorie restriction involving the...
Why Too Much NMN or NR is Bad
High levels of NAM can have many negative effects such as inhibiting sirtuins, which is the opposite of what you are trying to accomplish by taking NAD+ boosters. The body...
Why Too Much NMN or NR is Bad
High levels of NAM can have many negative effects such as inhibiting sirtuins, which is the...
Reduced Nicotinamide Mononucleotide - A Tale of...
NAD+ Precursors and Healthy Aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It is a critical coenzyme for energy metabolism and also serves as the...
Reduced Nicotinamide Mononucleotide - A Tale of...
NAD+ Precursors and Healthy Aging Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living...
NAD+ and the Hallmarks of Aging Series - Part 5...
Growth Hormone and Insulin Growth hormone is a well-known hormone that promotes the growth and proliferation of cells. Its secondary mediator, insulin-like growth factor 1 (IGF-1), is produced in response...
NAD+ and the Hallmarks of Aging Series - Part 5...
Growth Hormone and Insulin Growth hormone is a well-known hormone that promotes the growth and proliferation...
Bacteria in Gastrointestional Tract Metabolize ...
This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that oral NMN takes to becoming NAD+ in mice. It confirmed some aspects of earlier...
Bacteria in Gastrointestional Tract Metabolize ...
This recently published research by Drs. Lindsay Wu, David Sinclair and others examined the pathways that...
CD73 utilization shows importance of NMN to res...
This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by CD73 enzyme in the cell membrane is a key mechanism to maintain intracellular NAD+...
CD73 utilization shows importance of NMN to res...
This recent study found that in endothelial cells, the extracellular conversion of NMN to NR by...
How NAD+ Boosts ATP and What it Means for Healt...
Much of the attention on the benefits of restoring NAD+ levels focus on its role in activating sirtuins. However, scientific research shows that NAD supplementation has a clear beneficial effect...
How NAD+ Boosts ATP and What it Means for Healt...
Much of the attention on the benefits of restoring NAD+ levels focus on its role in...
1st NMN Human Study Demonstrates Safety and Fas...
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be...
1st NMN Human Study Demonstrates Safety and Fas...
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing...
NAD+ IV increases NAD+ levels in blood plasma 4...
This study was just published that documented changes in plasma and urine levels of NAD+ and its metabolites during and after 750 mg NAD+ intravenous (IV) infusion. A Pilot Study...
NAD+ IV increases NAD+ levels in blood plasma 4...
This study was just published that documented changes in plasma and urine levels of NAD+ and...
NAD+ IV increases NAD+ levels in blood plasma 4...
In summary, this study revealed for the first time that: (a) at a flow rate of 3 μmole/min all exogenously infused NAD+ was rapidly and completely removed from the plasma...
NAD+ IV increases NAD+ levels in blood plasma 4...
In summary, this study revealed for the first time that: (a) at a flow rate of...
NAD+ is the Transport Molecule Used by the Body...
The benefits noted from supplementation with NR in recent research are from increased NAD+ circulating in the bloodstream, not NR. Sublingual NAD+ or NMN are likely much more efficient methods...
NAD+ is the Transport Molecule Used by the Body...
The benefits noted from supplementation with NR in recent research are from increased NAD+ circulating in...
Slc12a8 Does not Solve the Bioavailability Prob...
This research was published in January 2019 that found an enzyme named Slc12a8 that can transport a small quantity of Nicotinamide Mononucleotide (NMN) directly into some cells.
Slc12a8 Does not Solve the Bioavailability Prob...
This research was published in January 2019 that found an enzyme named Slc12a8 that can transport...