Latest Breakthroughs in NAD+ Research: What the Science Says in 2025

NAD levels
NAD+

Every cell in your body relies on NAD+ (nicotinamide adenine dinucleotide) to generate energy, repair DNA, and maintain healthy function. But as you age, NAD+ levels decline, making it harder for your body to keep up with cellular repair, immune defense, and metabolic balance. This drop is linked to fatigue, cognitive decline, and an increased risk of age-related conditions.

The good news? You can take steps to support and sustain NAD+ levels with science-backed strategies:

  • Eat for Cellular Health – Foods rich in vitamin B3 (like meat, fish, and whole grains) provide key NAD+ precursors to fuel production.
  • Exercise Regularly – Movement stimulates NAD+ synthesis and enhances mitochondrial efficiency, helping your cells generate more energy.
  • Intermittent Fasting – Short periods of fasting activate pathways that boost NAD+ and promote cellular repair.
  • Targeted Supplementation – NMN and NR are direct precursors to NAD+, helping replenish stores and counteract natural depletion.
  • Reduce NAD+ Depleters – Alcohol, smoking, and environmental stressors accelerate NAD+ loss by increasing oxidative damage and inflammation.

Research shows that supporting NAD+ can enhance brain function, protect heart health, and slow cellular aging. By incorporating these strategies into your routine, you can help maintain vitality, resilience, and longevity at the cellular level.

Take charge of your health today. Learn more about NAD+ and how to optimize your levels.


 

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Heather

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Heather L. Makar is a biologist, longevity futurist, TEDx speaker, and science writer focused on translating complex mechanisms of aging into strategies for healthspan extension. At Renue By Science, she leads research-driven content strategy that empowers readers to understand, optimize, and evolve their own biology. She brings a multidisciplinary perspective to health optimization, bridging natural medicine and cutting edge science to build actionable protocols that have tangible effects immediately and far into the future.

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