Research
Nicotinamide Riboside Shows Promise in Treating...
“Depletion of nicotinamide adenine dinucleotide (NAD)+ has been reported in patients with WS, suggesting a key role in the pathogenesis of WS.” Key Points No serious adverse effects reported NR...
Nicotinamide Riboside Shows Promise in Treating...
“Depletion of nicotinamide adenine dinucleotide (NAD)+ has been reported in patients with WS, suggesting a key...
Oral NAD+: Revisiting Assumptions about Efficacy
Image source: Alegre, et al., 2025 For years, NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) have been leading choices for raising NAD+ levels. Their popularity stems from the limitations of...
Oral NAD+: Revisiting Assumptions about Efficacy
Image source: Alegre, et al., 2025 For years, NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) have...
NR Improved Brain and Blood Vessel Health in Ad...
Key Points Blood vessel function improved after 4 weeks of NR supplementation Brain blood flow increased in areas linked to memory and decision-making Participants showed modest gains in cognitive tests,...
NR Improved Brain and Blood Vessel Health in Ad...
Key Points Blood vessel function improved after 4 weeks of NR supplementation Brain blood flow increased...
Safety of IV Nicotinamide Riboside at Different...
Key Points IV NR was well tolerated at doses up to 450 mg/kg High doses (600 mg/kg) caused negative effects, including cardiovascular, liver, and kidney damage Increasing Doses of IV...
Safety of IV Nicotinamide Riboside at Different...
Key Points IV NR was well tolerated at doses up to 450 mg/kg High doses (600...
NR Boosts Fat-Burning Activity in Obese Mice
What is Brown Fat and Why is it Important? Brown fat, or brown adipose tissue (BAT), is a special type of body fat that burns energy to produce heat -...
NR Boosts Fat-Burning Activity in Obese Mice
What is Brown Fat and Why is it Important? Brown fat, or brown adipose tissue (BAT),...
NMN Offers More Protection Than NR in Friedreic...
Key Points: NMN and NR provided several benefits in mice with FRDA and highlighted key differences between the two treatments: NMN more effectively restored NAD+ levels in the heart than...
NMN Offers More Protection Than NR in Friedreic...
Key Points: NMN and NR provided several benefits in mice with FRDA and highlighted key differences...
NR IV Exhibits Faster NAD+ Rise and Better Tole...
“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more tolerable.”
NR IV Exhibits Faster NAD+ Rise and Better Tole...
“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more...
NMN More Effective Than NR for NAFLD in Mice
Key Points NMN and NR provided benefits in mice on a high-fat diet (HFD), but NMN offered more significant protection against NAFLD: Both NMN and NR prevented weight gain and...
NMN More Effective Than NR for NAFLD in Mice
Key Points NMN and NR provided benefits in mice on a high-fat diet (HFD), but NMN...
NMN and NR Alleviate Ovarian Aging in Rats
A recent study investigated the effects of NMN and NR on ovary health and function in middle-aged rats. “This study reveals that NMN alone or NR alone can rebalance mitochondrial...
NMN and NR Alleviate Ovarian Aging in Rats
A recent study investigated the effects of NMN and NR on ovary health and function in...
Liposomal delivery of NR shows increased bioava...
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
Liposomal delivery of NR shows increased bioava...
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially...
Niacin, NMN, and NR Are Not The Same
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within the body are distinct. Understanding these individual pathways is crucial, as they may have...
Niacin, NMN, and NR Are Not The Same
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within...
Enhanced NMN Detection Validates Slc12a8-Depend...
“We have demonstrated that this methodology can accurately quantitate NMN levels in mouse plasma and confirmed quick, direct NMN uptake into blood circulation and cells.”
Enhanced NMN Detection Validates Slc12a8-Depend...
“We have demonstrated that this methodology can accurately quantitate NMN levels in mouse plasma and confirmed...