Research
NMN Triples NAD+ Levels in Humans
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of...
NMN Triples NAD+ Levels in Humans
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice...
Why Dr. Sinclair takes NMN instead of NR
“NMN makes mice run further. Old mice can run 50% further, because they have better blood flow, better energy. NR at the same dose did not do that. In fact...
Why Dr. Sinclair takes NMN instead of NR
“NMN makes mice run further. Old mice can run 50% further, because they have better blood...
Lower Inflammation to Raise NAD+
Results from hundreds of tests for Intracellular NAD+ levels tell us that those with high inflammation levels (measured by HS-CRP) have less success raising NAD+ levels.Lowering inflammation can help restore...
Lower Inflammation to Raise NAD+
Results from hundreds of tests for Intracellular NAD+ levels tell us that those with high inflammation...
NAD+ and the Hallmarks of Aging Series – Part 8...
Altogether, these studies suggest that the decline of stem cell number and function is a hallmark of aging and is a major cause of decreased tissue homeostasis in the old...
NAD+ and the Hallmarks of Aging Series – Part 8...
Altogether, these studies suggest that the decline of stem cell number and function is a hallmark...
NAD+ and the Hallmarks of Aging Series - Part 6...
These findings suggest that a conserved pathway may operate in mammals during calorie restriction involving the activation of SIRT1 and increased NAD+ that triggers an increase in mitochondrial activity, which...
NAD+ and the Hallmarks of Aging Series - Part 6...
These findings suggest that a conserved pathway may operate in mammals during calorie restriction involving the...
Why Too Much NMN or NR is Bad
High levels of NAM can have many negative effects such as inhibiting sirtuins, which is the opposite of what you are trying to accomplish by taking NAD+ boosters. The body...
Why Too Much NMN or NR is Bad
High levels of NAM can have many negative effects such as inhibiting sirtuins, which is the...
Reduced Nicotinamide Mononucleotide - A Tale of...
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are both well-known NAD+ precursors that can effectively increase NAD+ levels across multiple tissues. They are very similar to each other. In fact,...
Reduced Nicotinamide Mononucleotide - A Tale of...
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are both well-known NAD+ precursors that can effectively increase...
NAD+ and the Hallmarks of Aging Series - Part 5...
Growth Hormone and Insulin Growth hormone is a well-known hormone that promotes the growth and proliferation of cells. Its secondary mediator, insulin-like growth factor 1 (IGF-1), is produced in response...
NAD+ and the Hallmarks of Aging Series - Part 5...
Growth Hormone and Insulin Growth hormone is a well-known hormone that promotes the growth and proliferation...
Bacteria in Gastrointestional Tract Metabolize ...
Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, 4 hours after a single dose of either 50mg/kg or 500 mg/kg by oral...
Bacteria in Gastrointestional Tract Metabolize ...
Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver,...
CD73 utilization shows importance of NMN to res...
Like prior studies (1), they found that this transport method did not impede NMN from entering cells, as NR and NMN performed equally at restoring NAD+. They also determined that...
CD73 utilization shows importance of NMN to res...
Like prior studies (1), they found that this transport method did not impede NMN from entering...
How NAD+ Boosts ATP and What it Means for Healt...
Declining ATP as we age Adenosine triphosphate (ATP) is the main biological fuel used by our body. It provides every cell with energy for the essential processes such as muscle...
How NAD+ Boosts ATP and What it Means for Healt...
Declining ATP as we age Adenosine triphosphate (ATP) is the main biological fuel used by our...
1st NMN Human Study Demonstrates Safety and Fas...
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be...
1st NMN Human Study Demonstrates Safety and Fas...
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing...