Key Points
- No adverse effects observed
- NAD+ levels increased significantly
- Overdose levels had no side effects
“The aim of this study was to confirm the safety of our manufactured NMN under conditions of overdose intake of up to six-fold the daily recommended intake level.”
Methods
30 healthy individuals aged 20-64 were split into three groups for a four-week trial.
- High-dose: 1,500 mg/day NMN
- Low-dose: 750 mg/day NMN
- Placebo: 0 mg/day
“To evaluate the safety of overdose intake of NMN, we conducted medical interviews and examined subjective symptoms, body weight, body mass index, blood pressure, pulse rate, hematological testing, biochemical testing, and urine testing at 0, 2, and 4 weeks of intake.”
High Dose NMN Well Tolerated
No adverse effects were reported in any group. Mild fluctuations in certain biomarkers were observed, all within a normal range.
“We found no problematic findings or test result changes during any medical interviews or tests throughout the study period, confirming the safety of 1,500 mg/day NMN ingestion for 4 weeks.”
The study found no safety concerns even at six times the daily recommended dose, reinforcing a strong therapeutic profile.
NAD+ Significantly Increased
Nicotinamide adenine dinucleotide (NAD+) saw dose dependent increases, confirming the efficacy of NMN as a precursor to raise NAD+ levels.
“Blood nicotinamide adenine dinucleotide (NAD+) levels increased significantly, suggesting that orally ingested NMN was transferred throughout the body and converted to NAD+.”
This data shows elevated blood NAD+ levels at the two week mark for both the high-dose (black squares) and low-dose (black circles) group, remained constant through the end of the study.
“Our results confirmed that NMN intake was associated with significant increases in blood NAD+ levels in a dose-dependent manner…
…Blood NAD+ levels plateaued at 2 weeks in the high and low-dose groups and blood concentration levels were maintained until 4 weeks.”
These findings support the ability of NMN to boost NAD+ levels sustainably, even at high intake levels.
Telomere Observations
Researchers assessed telomere length data but found no significant changes, concluding NMN had no effect on telomere length.
“Blood cell telomere length was also observed but found to have no significant effects.”
Conclusion
This study further supports NMN as an effective way to raise blood NAD+ levels, even at high doses, with no adverse effects.
“NMN caused no adverse reactions or problematic changes in safety markers such as blood markers, confirming the safety of overdose intake.”
As research continues to evolve, NMN remains a promising longevity compound to support better aging.
