Personalized Longevity: Tailoring Health Strate...

The Biology of Aging: Understanding Core Mechanisms Hallmarks of Aging The fundamental processes driving aging include genomic instability arising from DNA damage caused by environmental stressors and internal factors like...

Open Access Government: A century of NAD+ insig...

Nicotinamide adenine dinucleotide. NAD+ is essential for human health and is central to cellular metabolism, DNA repair, and many other essential operations.

Rethinking the Reproductive Clock: Can NAD+ Pre...

Synopsis   Peak fertility occurs around age 25, begins declining after 30, and accelerates after 35. Women are born with a fixed number of oocytes forming the ovarian reserve, and...

Mitochondrial Function for Healthy Aging: Targe...

Understanding Aging Mechanisms Aging involves a complex network of dysregulated mechanisms originally identified as nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing,...

A Century of NAD+ Insights Drives Aging Science...

Synopsis   Today, research reveals that NAD+ levels naturally decline with age, dropping approximately 50% between ages 40 and 60. This decline directly impacts cellular energy metabolism, DNA repair, and...