Recommended 2 Pumps

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Name: Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)
Brand: Renue Store
SKU: 850055685215
Price: 60.0 USD
Availability: InStock

Convenient cognitive boost

$60.00 USD

Product variants

Shipping calculated at checkout.

If you’re looking for a convenient on-the-go product, our NAD+ nasal spray is the perfect complement to your main NAD+ supplements.

The NAD+ nasal spray provides targeted delivery, focusing on the brain, rather than widespread systemic circulation. It’s designed to have a stronger effect on cognition and brain fog than all other delivery methods.†

Recommended 2 Pumps

View full details

Clinical Trial: Evaluating the Efficacy of Liposomal NMN

A double-blind, placebo-controlled clinical trial was conducted with 15 healthy men aged 40 and older to measure the effects of NMN supplementation. Participants were randomly assigned to one of three groups (5 per group) and took their assigned supplement daily after breakfast for four weeks.

Placebo Group: Maltodextrin (4g/day)
Standard NMN Group: Non-liposomal NMN (350 mg/day)
Liposomal NMN Group: Liposomal NMN (350 mg/day)

Blood NAD+ levels were measured at four time points:

1. Before supplementation (baseline)
2. One hour after the first dose
3. After four weeks of daily supplementation
4. Four weeks after stopping supplementation

This study design allowed researchers to assess not just how effectively each form of NMN raised NAD+ levels, but also how long those effects persisted after supplementation ended.

NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

Liposomal NMN Increased Blood NAD+ Levels By 84%

After four weeks of supplementation, the Liposomal NMN Group exhibited an 84% increase in blood NAD+ levels, rising from 28.6 µM (baseline) to 52.5 µM.

Although NAD+ levels declined four weeks after participants stopped supplementation, they remained elevated at 36 µM compared to the baseline of 28.6 µM.

Encapsulated NMN Boosted NAD+ More Effectively Than Standard NMN

Among all groups, Liposomal NMN produced the greatest increase in NAD+ levels after four weeks, outperforming both Standard NMN and placebo.

Learn More about the Study HERE

Which NAD+ Precursor Is Best?

NAD+

This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN

This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR

This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline

Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Learn More About Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. (1)

This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Research

Liposomes Increase Bioavailability

With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.

For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.

With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.

Hence the study below shows it is about 10x more bioavailable.

Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.

Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.