Research
NMN Triples NAD+ Levels in Humans
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of...
NMN Triples NAD+ Levels in Humans
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice...
Why Dr. Sinclair takes NMN instead of NR
“NMN makes mice run further. Old mice can run 50% further, because they have better blood flow, better energy. NR at the same dose did not do that. In fact...
Why Dr. Sinclair takes NMN instead of NR
“NMN makes mice run further. Old mice can run 50% further, because they have better blood...
Lower Inflammation to Raise NAD+
Results from hundreds of tests for Intracellular NAD+ levels tell us that those with high inflammation levels (measured by HS-CRP) have less success raising NAD+ levels.Lowering inflammation can help restore...
Lower Inflammation to Raise NAD+
Results from hundreds of tests for Intracellular NAD+ levels tell us that those with high inflammation...
David Sinclair's Supplement Stack and Longevity...
David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field of longevity research. In a recent video, titled “Dr David Sinclair – Defeating Ageing...
David Sinclair's Supplement Stack and Longevity...
David Sinclair, a professor at Harvard University is perhaps the foremost expert in the growing field...
NAD+ and the Hallmarks of Aging Series – Part 8...
Altogether, these studies suggest that the decline of stem cell number and function is a hallmark of aging and is a major cause of decreased tissue homeostasis in the old...
NAD+ and the Hallmarks of Aging Series – Part 8...
Altogether, these studies suggest that the decline of stem cell number and function is a hallmark...
Trimethylglycine (TMG) for Restoring Methylatio...
TMG is a critical cofactor in methylation, which occurs in every mammalian cell donating methyl groups. This includes the synthesis of neurotransmitters such as serotonin and dopamine.
Trimethylglycine (TMG) for Restoring Methylatio...
TMG is a critical cofactor in methylation, which occurs in every mammalian cell donating methyl groups....
NAD+ and the Hallmarks of Aging Series - Part 6...
These findings suggest that a conserved pathway may operate in mammals during calorie restriction involving the activation of SIRT1 and increased NAD+ that triggers an increase in mitochondrial activity, which...
NAD+ and the Hallmarks of Aging Series - Part 6...
These findings suggest that a conserved pathway may operate in mammals during calorie restriction involving the...
Why Too Much NMN or NR is Bad
High levels of NAM can have many negative effects such as inhibiting sirtuins, which is the opposite of what you are trying to accomplish by taking NAD+ boosters. The body...
Why Too Much NMN or NR is Bad
High levels of NAM can have many negative effects such as inhibiting sirtuins, which is the...
Reduced Nicotinamide Mononucleotide - A Tale of...
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are both well-known NAD+ precursors that can effectively increase NAD+ levels across multiple tissues. They are very similar to each other. In fact,...
Reduced Nicotinamide Mononucleotide - A Tale of...
Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are both well-known NAD+ precursors that can effectively increase...
NAD+ and the Hallmarks of Aging Series - Part 5...
Growth Hormone and Insulin Growth hormone is a well-known hormone that promotes the growth and proliferation of cells. Its secondary mediator, insulin-like growth factor 1 (IGF-1), is produced in response...
NAD+ and the Hallmarks of Aging Series - Part 5...
Growth Hormone and Insulin Growth hormone is a well-known hormone that promotes the growth and proliferation...
Study Shows NMN Supplementation or CD38 Inhibit...
Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It was demonstrated that raising NAD+ levels through NMN supplementation or by CD38 inhibition can restore cardiovascular function...
Study Shows NMN Supplementation or CD38 Inhibit...
Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It was demonstrated that...
Bacteria in Gastrointestional Tract Metabolize ...
Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, 4 hours after a single dose of either 50mg/kg or 500 mg/kg by oral...
Bacteria in Gastrointestional Tract Metabolize ...
Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver,...