Page Under Review
THE LIPOSOME ADVANTAGE
THE LIPOSOME ADVANTAGE
Liposomes are a revolutionary way of encapsulating active ingredients to protect them from stomach acid and enzymes to deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1
Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
– Research on Bioavailability with Liposomes
Solves the Bioavailability Problem
Solves the Bioavailability Problem
The aim of taking any supplement is to ensure it’s transport into the bloodstream via the mucosal membrane and intestinal epithelial cells.
However, due to the low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2
Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.
Targeted Delivery
Targeted Delivery
Liposomal delivery offers a targeted and nearly complete absorption of active ingredients with a delayed‑release effect, unlike other nutrient delivery methods. This increased circulation time of specific nutrients in the bloodstream significantly increases bioavailability. The higher the bioavailability of an active compound, the greater effect it has on the body.3
Advanced Absorption
Advanced Absorption
Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, skipping first-pass metabolism and breakdown in the liver. This ensures retention of intact liposomes to enter into circulation. Synthesis takes place inside cells which allows vitamins, minerals, or micronutrients to be utilized more easily. This higher absorption means greater efficacy and smaller doses needed to achieve better results.4
Biocompatibility
Biocompatibility
Phospholipids, which are found throughout the body in the membranes of cells are so naturally-occurring that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and therefore does not mount an immune attack on the liposome.5
Masking
Masking
Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination.
Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6
Crosses the Blood-Brain Barrier
Crosses the Blood-Brain Barrier
Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the active ingredients directly into the cells and enhance the circulation of nutrients by your lymphatic system.7
Nanoscale Power
Nanoscale Power
This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8
What are Liposomes made of?
The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).
The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.
The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.
The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system, improving its oral bioavailability and increasing peak plasma concentration. 9
What does phosphatidylcholine do?
What does phosphatidylcholine do?
Phosphatidylcholine (PC) is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function.
At birth, up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10
How do Liposomes work?
How do Liposomes work?
Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolong retention time.
At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution.
The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after released from the liposome.
These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances.
Liposomes ensure the safe delivery of encapsulated cargo nutrients and retain them in tissues and cells.
References
1. Potential of Liposomes for Enhancement of Oral Drug Absorption
2. Nanocarriers for oral drug delivery
3. Composition design and medical application of liposomes
4. Liposomal Delivery Systems: Design Optimization and Current Applications
5. Oral Bioavailability: Issues and Solutions via Nanoformulations
6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery
7. Stabilization of liposomes during drying
8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides
9. Scalable solvent-free production of liposomes
10. Membrane lipids: where they are and how they behave
Key Advantages of Liposomal Delivery:
Key Advantages of Liposomal Delivery:
Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
Optimizes bioavailability of both hydrophilic and hydrophobic, unstable compounds.
Timing of the dose intake does not require accompaniment or exclusion of food as liposomal absorption avoids the digestive processes.
Provides a larger nutrient payload per particle.
Offers higher bioavailability and absorption compared to conventional capsules.
Increases peak plasma concentration of encapsulated nutrients.
