60 Servings

Serving size 1 capsule

SLC 肠溶 NMN（烟酰胺单核苷酸，缓释）250 毫克

Name: SLC 肠溶 NMN（烟酰胺单核苷酸，缓释）250 毫克
Brand: Renue Store
SKU: 850055685055
Price: 2191.0 TWD
Availability: InStock

延迟释放 NAD+ 增强剂

$2,191.00 TWD

结账时计算的运费。

NMN 是一种已知能提高 NAD+ 水平的天然化合物。†

SLC NMN 旨在最大限度地提高 NMN 的吸收率、恢复甲基化并支持免疫系统。†

产品多属性

60 Servings

Serving size 1 capsule

SLC NMN Capsules

NAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. SLC NMN helps boost NAD+ production by providing NMN, a direct precursor to NAD+.†

“Together, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration.” (1)

Nicotinamide mononucleotide (NMN) is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:

Energy production†
DNA repair†
Regulation of genes†
Cellular health and vitality†
Immune function†
Regulation of the sleep-wake cycle†

NAD+ levels naturally decline with age, which research suggests is linked to the onset and progression of age-related diseases.† This makes increasing NAD+ levels a promising therapeutic target.†

NMN serves as a direct precursor to NAD+, acting as a potent booster to elevate your NAD+ levels.†

SLC NMN is designed for enhanced absorption by promoting its interaction with the NMN transporter, Slc12a8.†

The NMN Transporter – Slc12a8

A 2019 study found some NMN can be transported directly through the cell membrane by the Slc12a8 Transporter and converted to NAD+ inside the small intestine.

The results from their study showed that older mice had increased levels of the transporter, leading to greater increases in NAD+ levels after NMN supplementation compared to young mice.

“Therefore, increasing NMN availability or stimulating the function of the NMN transporter could effectively counteract age-associated NAD+ decline in the aged small intestine.”

Protecting NMN from Digestion by Bacteria is Key

However, another study showed that most NMN is degraded by bacteria in your gut, limiting the amount of NAD+ that can be produced from standard NMN formulations.

These figures show the effect of gut bacteria on the intestinal levels of NMN (on the left) and NAD+ (on the right) after NMN supplementation.

Gray bar: Normal, untreated mice
Yellow bar: Mice receiving antibiotics
Blue bar: Mice receiving NMN
Red bar: Mice receiving antibiotics and NMN

The yellow and red bars represent mice given antibiotics to deplete their gut bacteria. Their levels are many times higher than mice with normal gut bacteria.

SLC NMN

SLC NMN uses a specially designed capsule that safeguards NMN from degradation by gut bacteria, ensuring that it arrives intact at the Slc12a8 transporter in your gut.†

This unique NMN formulation features a number of key advantages to enhances absorption through Slc12a8 and promote your overall well-being:

Acid-resistant capsules: SLC NMN capsules are designed to protect the NMN through the stomach, providing more intact NMN in the small intestine for uptake by SLC12a8†
Trimethylglycine (TMG): TMG is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity†
Sodium Bicarbonate: Sodium ions are needed for Slc12a8 to work properly, so we include them in our capsules along with NMN. This helps to ensure that more NMN is absorbed into your cells†

查看完整详细信息

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

NAD+ 对生命至关重要……但会随着年龄的增长而下降

NAD+ 前体和防御者可以保护年轻的 NAD+ 水平，以维持健康的能量、力量和认知。

哪种 NAD+ 前体最好？

NAD+

这种中心辅酶直接参与氧化还原反应，并作为能量产生酶活性的底物，包括 sirtuins 和聚（ADP-核糖）聚合酶 (PARPs)，它们调节细胞代谢、DNA 修复和表观遗传修饰。

纳米二核苷酸

这种 NAD+ 前体通过 Salvage 途径中的 NMNAT 酶直接转化为 NAD+，已被大量临床试验证明可以有效提高细胞内 NAD+ 水平，从而增强线粒体功能、能量产生和 NAD+ 依赖性酶的活性。

天然橡胶

这种 NAD+ 前体通过 Preiss-Handler 途径转化为 NAD+，还表现出提高细胞中 NAD+ 水平的能力。它支持细胞修复机制，特别是那些涉及 DNA 损伤反应和氧化应激缓解的机制。通过支持 NAD+ 水平，NR 促进 sirtuins 和 PARP 的激活，从而保护基因组稳定性并调节细胞代谢。

葫芦巴碱

葫芦巴碱促进细胞 NAD+ 生成的方式与 NMN 或 NR 不同。这种甲基化形式的烟酸具有多种优势：在血流中具有出色的稳定性、缓慢释放到目标组织中、不会引起潮红、防止胃消化以及直接增加肌肉组织中的 NAD+。

肠溶胶囊保护NMN

血液中的 NAD+ 水平由生产和消耗之间的微妙平衡决定。SLC NMN 通过提供 NMN（NAD+ 的直接前体）来帮助促进 NAD+ 的产生。†

“总之，这表明 NAD+ 恢复的多目标策略，例如使用前体与抑制剂和/或作用于 NAD+ 网络中其他关键点的激活剂相结合，可能是 NAD+ 恢复的最佳方法。”( 1 )

烟酰胺单核苷酸 (NMN) 是一种天然存在于所有细胞中的分子。它是 NAD+ 的前体，NAD+ 是以下物质的重要分子：

能量生产†
DNA 修复†
基因调控†
细胞健康和活力†
免疫功能†
睡眠-觉醒周期的调节

NAD+ 水平会随着年龄的增长而自然下降，研究表明这与与年龄相关的疾病的发生和发展有关。† 这使得提高 NAD+ 水平成为一个有希望的治疗目标。†

NMN 是 NAD+ 的直接前体，可作为强力的助推器来提升您的 NAD+ 水平。†

SLC NMN 旨在通过促进其与 NMN 转运蛋白 Slc12a8 的相互作用来增强吸收。†

NMN转运蛋白–Slc12a8

2019 年的一项研究发现，一些 NMN 可以通过 Slc12a8 转运蛋白直接穿过细胞膜，并在小肠内转化为 NAD+。

他们的研究结果表明，与年轻小鼠相比，老年小鼠的转运蛋白水平有所提高，因此补充 NMN 后 NAD+ 水平提高幅度更大。

“因此，增加 NMN 的可用性或刺激 NMN 转运蛋白的功能可以有效抵消老年小肠中与年龄相关的 NAD+ 下降。”

保护 NMN 不被细菌消化是关键

然而，另一项研究表明，大多数 NMN 会被肠道细菌降解，从而限制了标准 NMN 配方中可产生的 NAD+ 的数量。

这些图显示了补充 NMN 后肠道细菌对肠道中 NMN（左）和 NAD+（右）水平的影响。

灰色条：正常的、未经治疗的小鼠
黄色条：接受抗生素治疗的小鼠
蓝色条：接受 NMN 治疗的小鼠
红色条：接受抗生素和 NMN 治疗的小鼠

黄色和红色条代表被注射抗生素以消灭肠道细菌的老鼠。它们的水平比肠道细菌正常的老鼠高出许多倍。

SLC 纳米微球

SLC NMN 使用专门设计的胶囊，可保护 NMN 免受肠道细菌的降解，确保其完整到达肠道中的 Slc12a8 转运蛋白。†

这种独特的 NMN 配方具有许多关键优势，可以通过 Slc12a8 增强吸收并促进您的整体健康：

耐酸胶囊： SLC NMN 胶囊旨在保护 NMN 通过胃部，在小肠中提供更完整的 NMN，以供 SLC12a8† 吸收
三甲基甘氨酸 (TMG)： TMG 是一种对甲基化很重要的天然化合物，甲基化是健康衰老和长寿所必需的重要细胞过程†
免疫支持： SLC NMN 含有锌，这是免疫功能的重要营养素†
碳酸氢钠： Slc12a8 需要钠离子才能正常工作，因此我们将其与 NMN 一起添加到胶囊中。这有助于确保更多的 NMN 被吸收到您的细胞中†

常见问题

How Do Enteric (Acid-Resistant) Capsules Work?

The enteric coated (acid-resistant) capsules are specifically designed to protect ingredients from the harsh acidic stomach, while safeguarding them from being degraded and digested by bacteria and enzymes.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract - with NAD+ precursors being particularly vulnerable to this.

The enteric (acid-resistant) capsules safeguard the ingredients to support better absorption, and a slower release into the bloodstream.

How is SLC Different From Liposomal?

Delivery Systems to Improve Absorption

Several delivery systems have been developed to protect NAD+ and precursors from being broken down and to enhance their absorption.

In other products, we use advanced Liposomal technology which protect NAD+, NMN, and NR from degradation in the GI tract and liver, but this delivery system adds significant cost.

We are committed to providing diverse and effective delivery methods that cater to various budgets and preferences. We believe that enteric (acid-resistant) capsules are superior to the standard capsules sold online, offering improved absorption at a lower cost than our competitors.