Fisetin is a natural compound that supports healthy cells. LIPO Fisetin is designed to selectively target aging cells, fostering a clean and well-functioning internal environment.
LIPO Fisetin is also available in our combination product, Senolytique.
Fisetin is a flavonoid that is a natural polyphenol and antioxidant.
It’s found in strawberries, apples, onions, and other plants that are particularly good at getting rid of senescent or “Zombie cells,” Fisetin has been called “The King of Senolytics”.
Senescent Cells
One of the main reasons you age is due to cells no longer dividing as they get older.
These cells become useless and start to build up in your body triggering inflammation, gradually impairing your cellular function, and increasing your risk of age-related conditions.
Get Rid of “Zombie” Cells
Scientists refer to these as Senescent cells, but are more commonly called “Zombie” cells. They are like little poison factories that do no useful work, but instead emit cytokines, which trigger inflammation in neighboring cells.
Liposomal Delivery
Standard Fisetin has poor absorption and low bioavailability, and its levels in the blood quickly diminish after ingestion. To address this issue, LIPO Fisetin uses an advanced liposomal delivery system designed to improve the bioavailability, created for better absorption, and a slower release into the bloodstream.†.
In this study, liposomal Fisetin was shown to be 1.6 to 27x more bioavailable.
Learn More About Liposomal Delivery
Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. (1)
This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.
Are any of your liposomal products heat-sensitive?
The liposomal powder capsule products are not heat sensitive.
The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.
What's the difference between Liposomal vs. Delayed & Extended Release Caps?
Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.
Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).
In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.
What are the liquid and powdered liposome differences in bioavailability and stability?
Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.
Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.
What are the benefits of liposomal delivery? Are liposomes really better?
When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.
A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.
Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.
The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.