PRODUCT NEWS
This an exciting time for the field of longevity science, with a significant increase in NAD+ research and studies recently.
Here are some recent study recaps, and some highlights from the research discussed at the esteemed longevity conference - the 2023 Aging Research and Drug Discovery (ARDD) Meeting.
Research on NMN for Heart Health
Two clinical trials showed that NMN improved blood pressure and heart function in humans.
A randomized control trial evaluated the effect of NMN supplementation on cardiovascular function in individuals with high blood pressure. Patients with high blood pressure were divided into two groups:
- NMN group: 800 mg NMN daily with lifestyle modifications.
- Lifestyle modification group: lifestyle modifications only.
At the start of the study (baseline), both groups had similar NAD+ levels. After six weeks, the NMN + lifestyle modification group (red line) showed a 43% increase in NAD+ levels, whereas no significant changes were seen in the group that made lifestyle modifications without supplementation (blue line).
“NAD+ boosting therapy with nicotinamide mononucleotide (NMN) supplement reduced BP and ameliorated vascular dysfunction in hypertensive patients,” according to the study.
Findings:
Findings:
- Low NAD+ levels in the blood were associated with high blood pressure.
- CD38, a molecule that breaks down NAD+, was elevated in the main blood vessel of people with high blood pressure.
NMN Transporter
Two recent studies have confirmed prior research from 2019, which showed that NMN has its own transporter, slc12a8, and some NMN can be directly taken up by cells.
- Confirmation NMN enters some cells directly
- Enhanced NMN Detection Validates Slc12a8-Dependent Uptake
Interesting NR Studies
This NR study revealed improvements in lipid levels in the serum and liver, enhanced glucose metabolism, and prevented weight gain in mice fed a high-fat diet.
This study showed that NR protected mice from alcohol-induced damage to the intestinal lining.
High-dose NR (3,000 mg/day) was determined to be safe and didn't deplete methyl pools, according to a study on patients with Parkinson's Disease.
Highlights from the 2023 ARDD Conference
To investigate the effects of NAD+ levels on aging, Dr. Eduardo Chini and other researchers developed a mouse model in which young mice have tissue NAD+ levels comparable to those typically observed in older mice.
Findings:
- Mice with low NAD+ levels exhibit features of aging similar to older mice (hair discoloration, increased frailty, osteoporosis, eye disease).
- There are 159 genes that change in the same way with aged mice and with mice that have low NAD+ levels.
Insights from research at Dr. Joe Baur's laboratory:
Researchers have identified a transporter (slc25A51) responsible for moving NAD+ into the mitochondria. They increased the levels of slc25A51 in the liver regeneration mouse model.
Findings:
- This enhanced recovery and regeneration of the liver.
- The effect was similar to what was observed after NR supplementation.
CD38 degrades NMN and regulates NAD+ levels:
The accumulation of the NAD+-degrading enzyme, CD38, plays a key role in the age-related decline of NAD+ levels.
Research shows that CD38 degrades NMN even more than NAD+, and that controlling NMN availability has a significant effect on NAD+ levels.
Longevity Clips
These are just a small handful of the recent studies. We also have research reviews on other supplements. Explore more content on Longevity Clips, which features summaries of cutting-edge research on NAD+, NMN, NR, and other longevity-focused studies.
| VISIT LONGEVITY CLIPS |
Slow COMT and MTHFR and NMN
USER-SUBMITTED POST
Are there any studies on NMN outcomes and these two genetic components? It seems like the COMT and MTHFR communities are nebulous at best. Seems like nobody knows how to navigate these issues and it’s all trial and error.
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Senolytique, Quercetin, & Ashwagandha
USER-SUBMITTED POST
A poster mentioned a while ago not to mix Quercetin with Ashwagandha, but I can't find anything on the internet to support this or why. Any idea if it is a problem? For reference I have just started taking Senolytique (Quercetin, Fisetin, and Spermidine), but also usually take Ashwagandha most days. I also take NMN daily and TMG somedays.
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