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A recent study investigated the effects of NMN and NR on ovary health and function in of middle-aged rats.
“This study reveals that NMN alone or NR alone can rebalance mitochondrial dynamics by decreasing excessive fission in middle-aged rat ovaries, thus alleviating mitochondrial stress and correcting aging-induced folliculogenesis abnormalities.”
Key Points:
- NMN and NR improved ovarian function and follicle quality in middle-aged rats
- NMN and NR increased SIRT1 expression
- Effects were mediated through the rebalancing of mitochondrial dynamics
- NMN and NR were equally effective
Improved Ovarian Function and Follicle Quality
Ovarian index, a measure of ovarian health, was higher in rats treated with NMN and NR (0.143 and 0.142) compared to the middle-aged control group (0.134).
The number of corpus luteum, temporary structures in the ovary that form after an egg is released, were also higher in the NMN (9) and NR (7) groups compared to the control (5).
Older rats had higher FSH levels, a sign of lower ovary function. However, rats treated with NMN and NR had lower FSH levels, closer to the levels observed in young rats.
The LH/FSH ratio, an indicator of healthy ovulation, improved in the NMN (0.95) and NR (0.91) groups compared to the control (0.66).
NMN and NR Protected Follicle Integrity
NMN and NR prevented the degradation of follicles (atresia) that was observed in the untreated rats.
“NMN alone or NR alone improved follicle quality by reducing atresia.”
The number of healthy follicles was 31.25% and 25% higher in the NMN and NR groups compared to the control.
Additionally, NMN and NR reduced the number of dying follicles by 50% and 40% respectively.
Rebalanced of Mitochondrial Dynamics
Mitochondrial dynamics, a balance between fusion (indicating health) and fission (indicating decreased function), were disrupted in the ovaries of middle-aged rats.
NMN and NR treatment restored this balance by increasing the expression of fusion-related genes and proteins while decreasing those related to fission.
NMN and NR also increased the levels of SIRT1, a protein important for longevity, which was suppressed in the middle-aged control group.
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.
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| Use Code ALLNR15 for 15% Off All NR Formulas |
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